The Concept of Life in Modern Biology: A Theoretical Analysis of the Boundary between Living Things and Artificial Systems
Keywords:
Artificial Life, Concept of Life, Theoretical BiologyAbstract
This article examines the conceptual challenges surrounding the definition of life in modern biology, focusing on the boundaries between living organisms and artificial systems. The development of artificial life and synthetic biology challenges traditional definitions of life, which are based on classical biological features such as metabolism, reproduction, and homeostasis. Using a qualitative-philosophical approach through an in-depth literature review of theoretical biology, philosophy of biology, and artificial life research, this article maps contemporary debates about what constitutes “life.” A conceptual-reflective analysis is conducted to evaluate various definitions proposed in the recent literature, including those emphasizing the emergent nature of complex systems, open evolution, and the dynamic nature of organizational patterns. The results demonstrate that life is not simply a collection of empirical features but also encompasses organizational structures capable of autonomous self-maintenance through internal interactions with their environment. The phenomenon of artificial life provides important insights that features such as adaptation, evolution, and self-organization are not exclusive to natural biological entities, thus raising the need for a more inclusive and reflective definitional framework. In conclusion, the concept of life in modern biology is pluralistic and spectral, demanding an understanding that integrates empirical and philosophical approaches and opens up discussion for the integration of artificial life into contemporary theoretical biology. These findings have conceptual, methodological, and ethical implications for the future development of biology.
References
Artić, O., et al. (2024). A roadmap toward the synthesis of life. ScienceDirect. https://doi.org/10.1016/j.sbi.2024.6442
Artime, O., & De Domenico, M. (2022). From the origin of life to pandemics: Emergent phenomena. Philosophical Transactions of the Royal Society A, 380(20200410). https://doi.org/10.1098/rsta.2020.0410
Beekman & Jochemsen. (2023). The Science of Nature article on self-organization through semiosis. https://doi.org/10.1007/s13752-023-00432-6
Beer, R. D. (2024). (A)Life as it could be. Artificial Life, 30(4), 539–545. https://doi.org/10.1162/artl_a_00455
Bender, R., Kofman, K., Agüera y Arcas, B., & Levin, M. (2025). What lives? (preprint). arXiv:2505.15849. https://doi.org/10.48550/arXiv.2505.15849
Dorin, A., & Stepney, S. (2024). What is artificial life today, and where should it go? Artificial Life, 30(1), 1–15. (Editorial) https://doi.org/10.1162/artl_a_00400
Gershenson, C. (2023). Emergence in Artificial Life. Artificial Life, 29(2), 153–167. https://doi.org/10.1162/artl_a_00397
Gómez-Márquez, J. (2023). Reflections upon a new definition of life. The Science of Nature, 110(6). https://doi.org/10.1007/s00114-023-01882-5
Gómez-Márquez, J., & Beekman, W. (2023). Concepts of life and self-organization. The Science of Nature. https://doi.org/10.1007/s00114-023-01882-5
Grève, S. (2023). Artificial forms of life. Philosophies, 8(5), 89. https://doi.org/10.3390/philosophies8050089
Kumar, A., et al. (2024). Automating the search for artificial life with foundation models. arXiv:2412.17799. https://doi.org/10.48550/arXiv.2412.17799
Le, N. H., Watson, R., Levin, M., & Buckley, C. (2024). Emergent collective reproduction via evolving neuronal flocks. arXiv:2409.13254. https://doi.org/10.48550/arXiv.2409.13254
Luisi, P. L. (2024). Life from the edge of synthetic biology. Intellect. https://doi.org/10.1386/9781789387926_16
Martinez-Saito, M. (2025). Defining and finding lifelike entities with a lazy filter. arXiv:2504.14774. https://doi.org/10.48550/arXiv.2504.14774
Simondon, G. (2025). New encounters between life and technology: Synthetic biology’s challenge. Foundations of Science. https://doi.org/10.1007/s10699-025-09980-5
Weckström, M. M. (2025). On the prospects of theoretical biology: Life in the universe as an anomaly, a puzzle, and a counterinstance. Foundations of Science. https://doi.org/10.1007/s10699-025-09995-y
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Hendri Putra, Tatenda Ncube, Emmanuel Lungu, Ingrid Larsen (Author)

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.











